Puerarin extract puerarin is also known as Puerarin. It is an isoflavone derivative with crown-expanding effect isolated from the traditional Chinese medicine Pueraria lobata. Derived from the roots of Pueraria lobata (Willd) Ohwi and Pueraria thunbergiana Benth. The main chemical components are flavonoids Pueraria flavonoids, brown powder with low content, white needle-like crystal powder with high content, mp 187℃. Dissolved in methanol, slightly soluble in ethanol, slightly soluble in water, insoluble in chloroform or ether.
It has the effects of improving immunity, enhancing myocardial contractility, protecting myocardial cells, lowering blood pressure, and anti-platelet aggregation. It is widely used in the field of medicine.

 

Puerarin is a isoflavone that exists in a variety of plants, including some medicinal plants, especially the rhizomes of Pueraria plants, such as the traditional Chinese medicine Puerarin, and Pueraria lobata. Puerarin is an 8-C-glucoside of daidzein.
Clinically, it is used for coronary heart disease, angina pectoris, and hypertension.

 

 

 

 

CAS Number	3681-99-0	Molecular Weight	432.378
Density	1.6±0.1 g/cm3	Boiling Point	791.2±60.0 °C at 760 mmHg
Molecular Formula	C21H20O9	Melting Point	187-189°C
Common name	Puerarin	Flash Point	281.5±26.4 °C

 

 

 

Product name	Puerarin
Extract source	It is the dry root of the leguminous plant Pueraria lobata
Extraction Solvent	Ethyl alcohol
Appearance	White powder
Solubility	Dissolved in methanol, slightly soluble in ethanol, slightly soluble in water, insoluble in chloroform or ether.
Identification	TLC , HPLC
Sulphated Ash	NMT 0.5%
Heavy metals	NMT 20 PPM
Loss On Drying	NMT 5.0%
Powder size	80Mesh, NLT90%
Assay of Puerarin (HPLC test, percent, Standard in House)	Min. 95.0%
Residual Solvents
- N-hexane	NMT 290 PPM
- Methanol	NMT 3000 PPM
- Acetone	NMT 5000 PPM
- Ethyl Acetate	NMT 5000 PPM
- Ethanol	NMT 5000 PPM
Pesticide Residues
- Total DDT (Sum of p,p'-DDD,P,P'-DDE,o,p'-DDT and p,p' -DDT)	NMT 0.05 PPM
- Aldrin, Endrin, Dieldrin	NMT 0.01 PPM
Microbiological Quality (Total viable aerobic count)
- Bacteria, CFU/g, not more than	NMT 103
- Moulds and yeasts, CFU/g, not more than	NMT 102
- E.coli, Salmonella, S. aureus, CFU/g	Absence
Storage	In Tight, Light-resistant and Dry Place. Avoid Direct Sunshine.
Shelf life	24 months

 

 

 

1) Improve blood circulation of Puerarin extract puerarin
Puerarin is an isoflavone derivative extracted from pueraria lobata, which can expand blood vessels and improve blood circulation. It is commonly used to treat ischemic cardiovascular and cerebrovascular diseases such as coronary heart disease, myocardial infarction, cerebral infarction, cerebral thrombosis, and cerebral vasospasm.

2) Reduce myocardial oxygen consumption
Rational use of puerarin can effectively reduce myocardial oxygen consumption, alleviate symptoms of myocardial ischemia and hypoxia, and have a certain therapeutic effect on heart diseases such as coronary heart disease, angina pectoris, and myocardial infarction.

3) Improve microcirculation
The total puerarin in puerarin can reduce plasma renin activity and angiotensin, increase the amplitude of microvascular motion, increase local microvascular flow, improve the tissue state of retinal vascular endings, and improve visual function. Puerarin is also commonly used to treat diseases such as retinal arteriovenous occlusion, and atrophy of the optic nerve.

4) Anti cancer
Puerarin can inhibit cancer cells, and its rational use can play a certain role in preventing and fighting cancer.

 

Application

It is mainly used for the treatment of alcoholism, retinal artery and vein occlusion, sudden deafness, myocardial infarction , Coronary heart disease, angina pectoris, hypertension, hyperlipidemia and other diseases.

 

 

a. Contains saponins, which have a protective effect on liver tissue immune damage.

b. Can effectively reverse chemically induced liver fibrosis.

c. Enhance myocardial contractility and protect myocardial cells.

d. It can dilate blood vessels, lower blood pressure and improve microcirculation.

e. Protect the deformability of red blood cells and enhance the function of the hematopoietic system.

f. Anti-platelet aggregation, increase fibrinolytic activity, and reduce blood viscosity.

g. It has a protective effect on nephritis and renal failure models.

h. It has obvious regulatory effect on non-specific immunity, humoral immunity and cellular immunity.

i. It can promote the transformation rate of lymphocytes in normal people and tumor patients, and enhance the effect of natural hormones.

j. It has obvious stimulating and inducing effect on the interference system.

 

 

 

Puerarin can treat diabetes by reducing blood glucose concentration. Puerarin can up regulate insulin receptor substrate IRS-1 and insulin-like growth factor IGF-1 protein, and promote insulin receptor InsR and peroxisome proliferator activated receptor PPAR α To reduce blood sugar and treat diabetes. In addition, puerarin can also inhibit α- The activity of glucosidase can reduce the blood sugar concentration and achieve the purpose of treating diabetes. The study found that after puerarin treatment for type 2 diabetes patients, Chemicalbook can improve the body's sensitivity to insulin, and puerarin drugs can weaken insulin resistance, thus treating diabetes. Puerarin can also inhibit TNF in plasma- α It can improve the sensitivity of the body to insulin levels and reduce blood sugar content. In addition, the application of puerarin in diabetes retinopathy helps to reduce the blood flow resistance of the ophthalmic artery, speed up the blood flow, promote the expansion of the muscular artery, and reduce local thrombosis. It has a preventive effect on diabetes retinopathy, and puerarin also has a therapeutic effect on diabetes in pregnancy.

 

 

 

 

 

 

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